B-Cell-Specific Myd88 L252P Expression Causes a Premalignant Gammopathy Resembling IgM MGUS

B-Cell-Specific Myd88 L252P Expression Causes a Premalignant Gammopathy Resembling IgM MGUS

A highly recurrent somatic L265P mutation in the TIR domain of the signaling adapter MYD88 constitutively activates NF-κB. It occurs in nearly all human patients with Waldenström’s macroglobulinemia (WM), a B cell malignancy caused by IgM-expressing cells. Here, we introduced an inducible leucine to...

Full description

Bibliographic Details
Main Authors: Kristin Schmidt, Ulrike Sack, Robin Graf, Wiebke Winkler, Oliver Popp, Philipp Mertins, Thomas Sommermann, Christine Kocks, Klaus Rajewsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
monoclonal gammopathy of unknown significance
IgM MGUS
MYD88 L265P mutation
Waldenström’s macroglobulinemia
B cell abnormalities
B cell lymphoma
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.602868/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.602868/full

Similar Items