Protein complexes and proteolytic activation of the cell wall hydrolase RipA regulate septal resolution in mycobacteria.

Peptidoglycan hydrolases are a double-edged sword. They are required for normal cell division, but when dysregulated can become autolysins lethal to bacteria. How bacteria ensure that peptidoglycan hydrolases function only in the correct spatial and temporal context remains largely unknown. Here, we...

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Bibliographic Details
Main Authors: Michael C Chao, Karen J Kieser, Shoko Minami, Daniela Mavrici, Bree B Aldridge, Sarah M Fortune, Tom Alber, Eric J Rubin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3585148?pdf=render