The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases

The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases

Deubiquitinases (DUBs) play a critical role in ubiquitin-directed signaling by catalytically removing the ubiquitin from substrate proteins. Ubiquitin-specific protease 15 (USP15), a member of the largest subfamily of cysteine protease DUBs, contains two conservative cysteine (Cys) and histidine (Hi...

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Bibliographic Details
Main Authors: Chon-Kit Chou, Yu-Ting Chang, Michal Korinek, Yei-Tsung Chen, Ya-Ting Yang, Steve Leu, I-Ling Lin, Chin-Ju Tang, Chien-Chih Chiu
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:International Journal of Molecular Sciences
Subjects:
deubiquitinase
ubiquitin-specific protease 15
TGF-β
IκBα
cancer-related signaling networks
Parkinson’s disease
Online Access:http://www.mdpi.com/1422-0067/18/3/483

Internet

http://www.mdpi.com/1422-0067/18/3/483

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