DNA damage repair machinery and HIV escape from innate immune sensing

DNA damage repair machinery and HIV escape from innate immune sensing

Viruses have been long known to perturb cell cycle regulators and key players of the DNA damage response to benefit their life cycles. In the case of the human immunodeficiency virus (HIV), the viral auxiliary protein Vpr activates the structure-specific endonuclease SLX4 complex to promote escape f...

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Bibliographic Details
Main Authors: Christelle eBregnard, Monsef eBenkirane, Nadine eLaguette
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Microbiology
Subjects:
HIV
G2/M arrest
Vpr
innate immunity
DNA damage response
SLX4 complex
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00176/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00176/full

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