Effect of Interleukin-15 Receptor Alpha Ablation on the Metabolic Responses to Moderate Exercise Simulated by in vivo Isometric Muscle Contractions

Effect of Interleukin-15 Receptor Alpha Ablation on the Metabolic Responses to Moderate Exercise Simulated by in vivo Isometric Muscle Contractions

Lack of interleukin 15 receptor alpha (IL15RA) increases spontaneous activity, exercise capacity and protects from diet-induced obesity by enhancing muscle energy metabolism, suggesting a role as exercise mimetic for IL15RA antagonists. Using controlled in vivo muscle stimulation mimicking moderate...

Full description

Bibliographic Details
Main Authors: Emanuele Loro, Cholsoon Jang, William J. Quinn, Joseph A. Baur, Zoltan P. Arany, Tejvir S. Khurana
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Physiology
Subjects:
muscle
exercise
interleukin-15 receptor alpha
metabolomics
in vivo stimulation
exercise mimetics
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01439/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01439/full

Similar Items