Evaluation of the Anticancer Activity of a Bile Acid-Dihydroartemisinin Hybrid Ursodeoxycholic-Dihydroartemisinin in Hepatocellular Carcinoma Cells

Evaluation of the Anticancer Activity of a Bile Acid-Dihydroartemisinin Hybrid Ursodeoxycholic-Dihydroartemisinin in Hepatocellular Carcinoma Cells

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy in adults and accounts for 85–90% of all primary liver cancer. Based on the estimation by the International Agency for Research on Cancer in 2018, liver cancer is the fourth leading cause of cancer death globally. Dihydroarte...

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Bibliographic Details
Main Authors: Tzu-En Huang, Yi-Ning Deng, Jui-Ling Hsu, Wohn-Jenn Leu, Elena Marchesi, Massimo L. Capobianco, Paolo Marchetti, Maria Luisa Navacchia, Jih-Hwa Guh, Daniela Perrone, Lih-Ching Hsu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Pharmacology
Subjects:
hepatocellular carcinoma
bile acid-dihydroartemisinin hybrid
G0/G1 arrest
apoptosis
reactive oxygen species
mitochondrial membrane potential loss
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.599067/full

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https://www.frontiersin.org/articles/10.3389/fphar.2020.599067/full

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