Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice

Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice

Abstract When injected into genetically modified mice, aggregates of the amyloid-β (Aβ) peptide from the brains of Alzheimer’s disease (AD) patients or transgenic AD mouse models seed cerebral Aβ deposition in a prion-like fashion. Within the brain, Aβ exists as a pool of distinct C-terminal variant...

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Bibliographic Details
Main Authors: Alejandro Ruiz-Riquelme, Alison Mao, Marim M. Barghash, Heather H. C. Lau, Erica Stuart, Gabor G. Kovacs, K. Peter R. Nilsson, Paul E. Fraser, Gerold Schmitt-Ulms, Joel C. Watts
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Prion-like propagation
Amyloid-β
Knock-in mice
Strains
Online Access:https://doi.org/10.1186/s40478-021-01187-6

Internet

https://doi.org/10.1186/s40478-021-01187-6

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