Targeted Next-Generation Sequencing of Cancer-Related Genes in a Norwegian Patient Cohort With Head and Neck Squamous Cell Carcinoma Reveals Novel Actionable Mutations and Correlations With Pathological Parameters

Targeted Next-Generation Sequencing of Cancer-Related Genes in a Norwegian Patient Cohort With Head and Neck Squamous Cell Carcinoma Reveals Novel Actionable Mutations and Correlations With Pathological Parameters

BackgroundTargeted next-generation sequencing (NGS) is increasingly applied in clinical oncology to advance personalized treatment. Despite success in many other tumour types, use of targeted NGS panels for assisting diagnosis and treatment of head and neck squamous cell carcinomas (HNSCC) is still...

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Bibliographic Details
Main Authors: Harsh N. Dongre, Hilde Haave, Siren Fromreide, Fredrik A. Erland, Svein Erik Emblem Moe, Sophia Manueldas Dhayalan, Rasmus Kopperud Riis, Dipak Sapkota, Daniela Elena Costea, Hans Jorgen Aarstad, Olav K. Vintermyr
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Oncology
Subjects:
next-generation sequencing (NGS)
actionable mutation
pathological parameters
stromal desmoplasia
inflammation
head and neck squamous cell carcinoma (HNSCC)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.734134/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.734134/full

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