Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis.

Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis.

Mycobacterium tuberculosis (Mtb) mutants lacking rv1411c, which encodes the lipoprotein LprG, and rv1410c, which encodes a putative efflux pump, are dramatically attenuated for growth in mice. Here we show that loss of LprG-Rv1410 in Mtb leads to intracellular triacylglyceride (TAG) accumulation, an...

Full description

Bibliographic Details
Main Authors: Amanda J Martinot, Mary Farrow, Lu Bai, Emilie Layre, Tan-Yun Cheng, Jennifer H Tsai, Jahangir Iqbal, John W Annand, Zuri A Sullivan, M Mahmood Hussain, James Sacchettini, D Branch Moody, Jessica C Seeliger, Eric J Rubin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1005351

Internet

https://doi.org/10.1371/journal.ppat.1005351

Similar Items