Synaptic density in healthy human aging is not influenced by age or sex: a 11C-UCB-J PET study

Synaptic density in healthy human aging is not influenced by age or sex: a 11C-UCB-J PET study

Rationale: 11C-UCB-J binds to synaptic vesicle glycoprotein 2A, a protein ubiquitously expressed in presynaptic nerve terminals, and can therefore serve as in vivo proxy of synaptic density. There are discrepancies in postmortem data on stability of synaptic density with healthy aging. In this study...

Full description

Bibliographic Details
Main Authors: Laura Michiels, Aline Delva, June van Aalst, Jenny Ceccarini, Wim Vandenberghe, Mathieu Vandenbulcke, Michel Koole, Robin Lemmens, Koen Van Laere
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:NeuroImage
Subjects:
Synaptic density
Aging
PET
SV2A
11C-UCB-J
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811921001543

Internet

http://www.sciencedirect.com/science/article/pii/S1053811921001543

Similar Items