No relation between docetaxel administration route and high‐grade diarrhea incidence

No relation between docetaxel administration route and high‐grade diarrhea incidence

Abstract Oral administration of docetaxel in combination with the CYP3A4 inhibitor ritonavir is used in clinical trials to improve oral bioavailability of docetaxel. Diarrhea was the most commonly observed and dose‐limiting toxicity. This study combined preclinical and clinical data and investigated...

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Bibliographic Details
Main Authors: Jeroen J. M. A. Hendrikx, Frederik E. Stuurman, Ji‐Ying Song, Vincent A. deWeger, Jurjen S. Lagas, Hilde Rosing, Jos H. Beijnen, Alfred H. Schinkel, Jan H. M. Schellens, Serena Marchetti
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Pharmacology Research & Perspectives
Subjects:
diarrhea
oral docetaxel
toxicity
Online Access:https://doi.org/10.1002/prp2.633

Internet

https://doi.org/10.1002/prp2.633

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