Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease

Abstract 5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains. We measured levels of 5-methylcytosine and 5-hydroxymethylcytosine by enzyme-linked immunosorbent assay in DNA from post-mortem c...

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Bibliographic Details
Main Authors: Reinhard Stöger, Paula J. Scaife, Freya Shephard, Lisa Chakrabarti
Format: Article
Language:English
Published: Nature Publishing Group 2017-02-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-017-0007-3