Intra-patient Heterogeneity of BRAF and NRAS Molecular Alterations in Primary Melanoma and Metastases

Intra-patient Heterogeneity of BRAF and NRAS Molecular Alterations in Primary Melanoma and Metastases

Mutations in MAPK signalling genes are driver events in melanoma, and have therapeutic relevance in the metastatic and adjuvant setting. This study evaluated the intra-patient heterogeneity of BRAF, NRAS and c-KIT mutational status between 30 primary melanomas and 39 related metastases, using molecu...

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Bibliographic Details
Main Authors: Cristina Pellegrini, Ludovica Cardelli, Marina De Padova, Lucia Di Nardo, Valeria Ciciarelli, Tea Rocco, Gianluca Cipolloni, Marco Clementi, Alessio Cortellini, Alessandra Ventura, Pietro Leocata, Maria Concetta Fargnoli
Format: Article
Language:English
Published: Society for Publication of Acta Dermato-Venereologica 2020-01-01
Series:Acta Dermato-Venereologica
Subjects:
melanoma
metastases
braf
nras
c-kit
heterogeneity
Online Access: https://www.medicaljournals.se/jadv/content/html/10.2340/00015555-3382

Internet

https://www.medicaljournals.se/jadv/content/html/10.2340/00015555-3382

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