Therapeutic Effects of (5R)-5-Hydroxytriptolide on Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via lncRNA WAKMAR2/miR-4478/E2F1/p53 Axis

Therapeutic Effects of (5R)-5-Hydroxytriptolide on Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via lncRNA WAKMAR2/miR-4478/E2F1/p53 Axis

Rheumatoid arthritis (RA) is an autoimmune disease. Fibroblast-like synoviocytes (FLS) serve a major role in synovial hyperplasia and inflammation in RA. (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, shows promising therapeutic effects for RA and is now in phase II clinical trial...

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Bibliographic Details
Main Authors: Xinpeng Zhou, Duoli Xie, Jie Huang, Aiping Lu, Rongsheng Wang, Yehua Jin, Runrun Zhang, Cen Chang, Lingxia Xu, Linshuai Xu, Junyu Fan, Chao Liang, Dongyi He
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
(5R)-5-hydroxytriptolide
fibroblast-like synoviocytes
inflammation
WAKMAR2
miR-4478/E2F1/p53 axis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.605616/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.605616/full

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