Cell Sheets from Adipose Tissue MSC Induce Healing of Pressure Ulcer and Prevent Fibrosis via Trigger Effects on Granulation Tissue Growth and Vascularization

Cell Sheets from Adipose Tissue MSC Induce Healing of Pressure Ulcer and Prevent Fibrosis via Trigger Effects on Granulation Tissue Growth and Vascularization

We report a comparative study of multipotent mesenchymal stromal cells (MSC) delivered by injection, MSC-based cell sheets (CS) or MSC secretome to induce healing of cutaneous pressure ulcer in C57Bl/6 mice. We found that transplantation of CS from adipose-derived MSC resulted in reduction of fibros...

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Bibliographic Details
Main Authors: Natalya Alexandrushkina, Peter Nimiritsky, Roman Eremichev, Vladimir Popov, Mikhail Arbatskiy, Natalia Danilova, Pavel Malkov, Zhanna Akopyan, Vsevolod Tkachuk, Pavel Makarevich
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
cell sheet
mesenchymal stromal cells
wound healing
granulation tissue
angiogenesis
endothelial cells
Online Access:https://www.mdpi.com/1422-0067/21/15/5567

Internet

https://www.mdpi.com/1422-0067/21/15/5567

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