Early-onset Purkinje cell dysfunction underlies cerebellar ataxia in peroxisomal multifunctional protein-2 deficiency

Early-onset Purkinje cell dysfunction underlies cerebellar ataxia in peroxisomal multifunctional protein-2 deficiency

The cerebellar pathologies in peroxisomal diseases underscore that these organelles are required for the normal development and maintenance of the cerebellum, but the mechanisms have not been resolved.Here we investigated the origins of the early-onset coordination impairment in a mouse model with n...

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Bibliographic Details
Main Authors: Stephanie De Munter, Simon Verheijden, Esther Vanderstuyft, Ana Rita Malheiro, Pedro Brites, David Gall, Serge N. Schiffmann, Myriam Baes
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Neurobiology of Disease
Subjects:
Peroxisomes
β-Oxidation
Multifunctional protein-2
Purkinje cell
Ataxia
Axonal swellings
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116301528

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http://www.sciencedirect.com/science/article/pii/S0969996116301528

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