Lido-OH, a Hydroxyl Derivative of Lidocaine, Produced a Similar Local Anesthesia Profile as Lidocaine With Reduced Systemic Toxicities

Lido-OH, a Hydroxyl Derivative of Lidocaine, Produced a Similar Local Anesthesia Profile as Lidocaine With Reduced Systemic Toxicities

Background: lidocaine is one of the most commonly used local anesthetics for the treatment of pain and arrhythmia. However, it could cause systemic toxicities when plasma concentration is raised. To reduce lidocaine’s toxicity, we designed a hydroxyl derivative of lidocaine (lido-OH), and its local...

Full description

Bibliographic Details
Main Authors: Qinqin Yin, Weiyi Zhang, Bowen Ke, Jin Liu, Wensheng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
lidocaine
toxicity
efficacy
hydroxyl derivatives
local anaestesia
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.678437/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.678437/full

Similar Items