Defective lipid remodeling of GPI anchors in peroxisomal disorders, Zellweger syndrome, and rhizomelic chondrodysplasia punctata

Defective lipid remodeling of GPI anchors in peroxisomal disorders, Zellweger syndrome, and rhizomelic chondrodysplasia punctata

Many cell surface proteins in mammalian cells are anchored to the plasma membrane via glycosylphosphatidylinositol (GPI). The predominant form of mammalian GPI contains 1-alkyl-2-acyl phosphatidylinositol (PI), which is generated by lipid remodeling from diacyl PI. The conversion of diacyl PI to 1-a...

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Bibliographic Details
Main Authors: Noriyuki Kanzawa, Nobuyuki Shimozawa, Ronald J.A. Wanders, Kazutaka Ikeda, Yoshiko Murakami, Hans R. Waterham, Satoru Mukai, Morihisa Fujita, Yusuke Maeda, Ryo Taguchi, Yukio Fujiki, Taroh Kinoshita
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Journal of Lipid Research
Subjects:
glycosylphosphatidylinositol
plasmalogens
peroxisomal disorder
rhizomelic chondrodysplasia punctata
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520405590

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http://www.sciencedirect.com/science/article/pii/S0022227520405590

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