Chain length specificity for activation of cPLA2α by C1P: use of the dodecane delivery system to determine lipid-specific effects

Chain length specificity for activation of cPLA2α by C1P: use of the dodecane delivery system to determine lipid-specific effects

Previously, our laboratory demonstrated that ceramide-1-phosphate (C1P) specifically activated group IVA cytosolic phospholipase A2 (cPLA2α) in vitro. In this study, we investigated the chain length specificity of this interaction. C1P with an acyl-chain of ≥6 carbons efficiently activated cPLA2α in...

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Bibliographic Details
Main Authors: Dayanjan S. Wijesinghe, Preeti Subramanian, Nadia F. Lamour, Luciana B. Gentile, Maria H. Granado, Alicja Bielawska, Zdzislaw Szulc, Antonio Gomez-Munoz, Charles E. Chalfant
Format: Article
Language:English
Published: Elsevier 2009-10-01
Series:Journal of Lipid Research
Subjects:
ceramide-1-phosphate
ceramide kinase
prostaglandins
phospholipase A2
inflammation
arachidonic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520307069

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http://www.sciencedirect.com/science/article/pii/S0022227520307069

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