Remote Activation of a Latent Epitope in an Autoantigen Decoded With Simulated B-Factors

Remote Activation of a Latent Epitope in an Autoantigen Decoded With Simulated B-Factors

Mutants of a catalytically inactive variant of Proteinase 3 (PR3)—iPR3-Val103 possessing a Ser195Ala mutation relative to wild-type PR3-Val103—offer insights into how autoantigen PR3 interacts with antineutrophil cytoplasmic antibodies (ANCAs) in granulomatosis with polyangiitis (GPA) and whether su...

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Bibliographic Details
Main Authors: Yuan-Ping Pang, Marta Casal Moura, Gwen E. Thompson, Darlene R. Nelson, Amber M. Hummel, Dieter E. Jenne, Daniel Emerling, Wayne Volkmuth, William H. Robinson, Ulrich Specks
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
autoantigen
antigenicity
antineutrophil cytoplasmic antibody
Proteinase 3
B-factor
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02467/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02467/full

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