Impact of acute malaria on pre-existing antibodies to viral and vaccine antigens in mice and humans.

Impact of acute malaria on pre-existing antibodies to viral and vaccine antigens in mice and humans.

Vaccine-induced immunity depends on long-lived plasma cells (LLPCs) that maintain antibody levels. A recent mouse study showed that Plasmodium chaubaudi infection reduced pre-existing influenza-specific antibodies--raising concerns that malaria may compromise pre-existing vaccine responses. We exten...

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Bibliographic Details
Main Authors: Simran Banga, Jill D Coursen, Silvia Portugal, Tuan M Tran, Lisa Hancox, Aissata Ongoiba, Boubacar Traore, Ogobara K Doumbo, Chiung-Yu Huang, John T Harty, Peter D Crompton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4412709?pdf=render

Internet

http://europepmc.org/articles/PMC4412709?pdf=render

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