Design, synthesis, and evaluation of novel N'-substituted-1-(4-chlorobenzyl)-1H-indol-3-carbohydrazides as antitumor agents

Design, synthesis, and evaluation of novel N'-substituted-1-(4-chlorobenzyl)-1H-indol-3-carbohydrazides as antitumor agents

In continuity of our search for novel anticancer agents acting as procaspase activators, we have designed and synthesised two series of (E)-N′-benzylidene-carbohydrazides (4a–m) and (Z)-N'-(2-oxoindolin-3-ylidene)carbohydrazides (5a–g) incorporating 1-(4-chlorobenzyl)-1H-indole core. Bioevaluat...

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Bibliographic Details
Main Authors: Le Cong Huan, Duong Tien Anh, Pham-The Hai, Lai Duc Anh, Eun Jae Park, A Young Ji, Jong Soon Kang, Do Thi Mai Dung, Dao Thi Kim Oanh, Truong Thanh Tung, Dinh Thi Thanh Hai, Sang-Bae Han, Nguyen-Hai Nam
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
acetohydrazides
isatin
cytotoxicity
caspase activation
Online Access:http://dx.doi.org/10.1080/14756366.2020.1816997

Internet

http://dx.doi.org/10.1080/14756366.2020.1816997

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