Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

Arthritis affects different joints variably despite systemic inflammatory cues. Here the authors show anatomical differences in the transcriptome, epigenome and function of synovial fibroblasts that might affect susceptibility to site-specific joint diseases.

Bibliographic Details
Main Authors: Mojca Frank-Bertoncelj, Michelle Trenkmann, Kerstin Klein, Emmanuel Karouzakis, Hubert Rehrauer, Anna Bratus, Christoph Kolling, Maria Armaka, Andrew Filer, Beat A. Michel, Renate E. Gay, Christopher D. Buckley, George Kollias, Steffen Gay, Caroline Ospelt
Format: Article
Language:English
Published: Nature Publishing Group 2017-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14852

Internet

https://doi.org/10.1038/ncomms14852

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