Effect of first-line biologic initiation on glucocorticoid exposure in children hospitalized with new-onset systemic juvenile idiopathic arthritis: emulation of a pragmatic trial using observational data

Effect of first-line biologic initiation on glucocorticoid exposure in children hospitalized with new-onset systemic juvenile idiopathic arthritis: emulation of a pragmatic trial using observational data

Abstract Background Glucocorticoid exposure is a significant driver of morbidity in children with systemic juvenile idiopathic arthritis (sJIA). We determined the effect of early initiation of biologic therapy (IL-1 or IL-6 inhibition) on glucocorticoid exposure in hospitalized patients with new-ons...

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Bibliographic Details
Main Authors: Rosemary G. Peterson, Rui Xiao, Hannah Katcoff, Brian T. Fisher, Pamela F. Weiss
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Pediatric Rheumatology Online Journal
Subjects:
Juvenile systemic arthritis
Biological therapy
Glucocorticoids
Online Access:https://doi.org/10.1186/s12969-021-00597-z

Internet

https://doi.org/10.1186/s12969-021-00597-z

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