Pantothenate kinase-2 (Pank2) silencing causes cell growth reduction, cell-specific ferroportin upregulation and iron deregulation

Pantothenate kinase-2 (Pank2) silencing causes cell growth reduction, cell-specific ferroportin upregulation and iron deregulation

Pantothenate kinase 2 (Pank2) is a mitochondrial enzyme that catalyses the first regulatory step of Coenzyme A synthesis and that is responsible for a genetic movement disorder named Pank-associated neurodegeneration (PKAN). This is characterized by abnormal iron accumulation in the brain, particula...

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Bibliographic Details
Main Authors: Maura Poli, Manuela Derosas, Sara Luscieti, Patrizia Cavadini, Alessandro Campanella, Rosanna Verardi, Dario Finazzi, Paolo Arosio
Format: Article
Language:English
Published: Elsevier 2010-08-01
Series:Neurobiology of Disease
Subjects:
Pantothenate kinase
Ferroportin
Iron metabolism
Ferritin
Neurodegeneration with brain iron accumulation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110001063

Internet

http://www.sciencedirect.com/science/article/pii/S0969996110001063

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