Mutations in VP0 and 2C Proteins of Duck Hepatitis A Virus Type 3 Attenuate Viral Infection and Virulence

Mutations in VP0 and 2C Proteins of Duck Hepatitis A Virus Type 3 Attenuate Viral Infection and Virulence

Duck hepatitis A virus (DHAV) is prevalent worldwide and has caused significant economic losses. As the predominant serotype in China, DHAV-3 has become a major challenge to the local duck industry. Here the genetics and pathogenesis of a virulent DHAV-3 strain and its embryo-passaged strain were as...

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Bibliographic Details
Main Authors: Xingjian Wen, Jinlong Guo, Di Sun, Mingshu Wang, Dian Cao, Anchun Cheng, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Shun Chen, Renyong Jia, Ying Wu, Shaqiu Zhang, Sai Mao, Xumin Ou, Xiaoyue Chen, Yanling Yu, Ling Zhang, Yunya Liu, Bin Tian, Leichang Pan, Mujeeb Ur Rehman
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Vaccines
Subjects:
duck hepatitis A virus
genetics
pathogenicity
attenuation
hepatic injury
innate immune response
intense inflammation
cytokine
Online Access:https://www.mdpi.com/2076-393X/7/3/111

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https://www.mdpi.com/2076-393X/7/3/111

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