The Intra-nuclear SphK2-S1P Axis Facilitates M1-to-M2 Shift of Microglia via Suppressing HDAC1-Mediated KLF4 Deacetylation

The Intra-nuclear SphK2-S1P Axis Facilitates M1-to-M2 Shift of Microglia via Suppressing HDAC1-Mediated KLF4 Deacetylation

Sphingosine 1-phosphate (S1P) is involved in a variety of cellular responses including microglial activation and polarization. However, the impacts of S1P on ischemia-induced microglial activation and polarization remain unclear. In the present study, Sprague-Dawley rats were selected for middle cer...

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Bibliographic Details
Main Authors: Juan Ji, Juan Wang, Jin Yang, Xi-Peng Wang, Jing-Jing Huang, Teng-Fei Xue, Xiu-Lan Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
microglial polarization
Sphk2
S1P
KLF4
ischemia
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01241/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01241/full

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