Nonhuman primate to human immunobridging to infer the protective effect of an Ebola virus vaccine candidate

Nonhuman primate to human immunobridging to infer the protective effect of an Ebola virus vaccine candidate

Abstract It has been proven challenging to conduct traditional efficacy trials for Ebola virus (EBOV) vaccines. In the absence of efficacy data, immunobridging is an approach to infer the likelihood of a vaccine protective effect, by translating vaccine immunogenicity in humans to a protective effec...

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Bibliographic Details
Main Authors: Ramon Roozendaal, Jenny Hendriks, Thierry van Effelterre, Bart Spiessens, Liesbeth Dekking, Laura Solforosi, Dominika Czapska-Casey, Viki Bockstal, Jeroen Stoop, Daniel Splinter, Sarah Janssen, Ben van Baelen, Nadia Verbruggen, Jan Serroyen, Eline Dekeyster, Ariane Volkmann, Yvonne Wollmann, Ricardo Carrion, Luis D. Giavedoni, Cynthia Robinson, Maarten Leyssen, Macaya Douoguih, Kerstin Luhn, Maria Grazia Pau, Jerry Sadoff, An Vandebosch, Hanneke Schuitemaker, Roland Zahn, Benoit Callendret
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-020-00261-9

Internet

https://doi.org/10.1038/s41541-020-00261-9

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