Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation.

Genome-wide association meta-analyses (GWAMAs) conducted separately by two strata have identified differences in genetic effects between strata, such as sex-differences for body fat distribution. However, there are several approaches to identify such differences and an uncertainty which approach to...

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Bibliographic Details
Main Authors: Thomas W Winkler, Anne E Justice, L Adrienne Cupples, Florian Kronenberg, Zoltán Kutalik, Iris M Heid, GIANT consortium
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5531538?pdf=render