Curcumin, Hormesis and the Nervous System
Curcumin is a polyphenol compound extracted from the rhizome of <i>Curcuma longa Linn</i> (family <i>Zingiberaceae</i>) commonly used as a spice to color and flavor food. Several preclinical studies have suggested beneficial roles for curcumin as an adjuvant therapy in free r...
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MDPI AG
2019-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/11/10/2417 |
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doaj-3189f1395ff64d44b9d53b3f59036aaa2020-11-25T02:53:58ZengMDPI AGNutrients2072-66432019-10-011110241710.3390/nu11102417nu11102417Curcumin, Hormesis and the Nervous SystemMaria Concetta Scuto0Cesare Mancuso1Barbara Tomasello2Maria Laura Ontario3Andrea Cavallaro4Francesco Frasca5Luigi Maiolino6Angela Trovato Salinaro7Edward J. Calabrese8Vittorio Calabrese9Department of Biomedical and Biotechnological Sciences, University of Catania, Torre Biologica, Via Santa Sofia, 97–95125 Catania, ItalyFondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, Torre Biologica, Via Santa Sofia, 97–95125 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, Torre Biologica, Via Santa Sofia, 97–95125 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, Torre Biologica, Via Santa Sofia, 97–95125 Catania, ItalyDepartment of Clinical and experimental Medicine, Division of Endocrinology, University of Catania, 95125 Catania, ItalyDepartment of Medical and Surgery Sciences, University of Catania, 95125 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, Torre Biologica, Via Santa Sofia, 97–95125 Catania, ItalyDepartment of Environmental Health Sciences, School of Public Health and Health Science, University of Massachusetts, Amherst, MA 01003, USADepartment of Biomedical and Biotechnological Sciences, University of Catania, Torre Biologica, Via Santa Sofia, 97–95125 Catania, ItalyCurcumin is a polyphenol compound extracted from the rhizome of <i>Curcuma longa Linn</i> (family <i>Zingiberaceae</i>) commonly used as a spice to color and flavor food. Several preclinical studies have suggested beneficial roles for curcumin as an adjuvant therapy in free radical-based diseases, mainly neurodegenerative disorders. Indeed, curcumin belongs to the family of hormetins and the enhancement of the cell stress response, mainly the heme oxygenase-1 system, is actually considered the common denominator for this dual response. However, evidence-based medicine has clearly demonstrated the lack of any therapeutic effect of curcumin to contrast the onset or progression of neurodegeneration and related diseases. Finally, the curcumin safety profile imposes a careful analysis of the risk/benefit balance prior to proposing chronic supplementation with curcumin.https://www.mdpi.com/2072-6643/11/10/2417hormesisvitagenesantioxidantsheme oxygenase |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Maria Concetta Scuto Cesare Mancuso Barbara Tomasello Maria Laura Ontario Andrea Cavallaro Francesco Frasca Luigi Maiolino Angela Trovato Salinaro Edward J. Calabrese Vittorio Calabrese |
| spellingShingle |
Maria Concetta Scuto Cesare Mancuso Barbara Tomasello Maria Laura Ontario Andrea Cavallaro Francesco Frasca Luigi Maiolino Angela Trovato Salinaro Edward J. Calabrese Vittorio Calabrese Curcumin, Hormesis and the Nervous System Nutrients hormesis vitagenes antioxidants heme oxygenase |
| author_facet |
Maria Concetta Scuto Cesare Mancuso Barbara Tomasello Maria Laura Ontario Andrea Cavallaro Francesco Frasca Luigi Maiolino Angela Trovato Salinaro Edward J. Calabrese Vittorio Calabrese |
| author_sort |
Maria Concetta Scuto |
| title |
Curcumin, Hormesis and the Nervous System |
| title_short |
Curcumin, Hormesis and the Nervous System |
| title_full |
Curcumin, Hormesis and the Nervous System |
| title_fullStr |
Curcumin, Hormesis and the Nervous System |
| title_full_unstemmed |
Curcumin, Hormesis and the Nervous System |
| title_sort |
curcumin, hormesis and the nervous system |
| publisher |
MDPI AG |
| series |
Nutrients |
| issn |
2072-6643 |
| publishDate |
2019-10-01 |
| description |
Curcumin is a polyphenol compound extracted from the rhizome of <i>Curcuma longa Linn</i> (family <i>Zingiberaceae</i>) commonly used as a spice to color and flavor food. Several preclinical studies have suggested beneficial roles for curcumin as an adjuvant therapy in free radical-based diseases, mainly neurodegenerative disorders. Indeed, curcumin belongs to the family of hormetins and the enhancement of the cell stress response, mainly the heme oxygenase-1 system, is actually considered the common denominator for this dual response. However, evidence-based medicine has clearly demonstrated the lack of any therapeutic effect of curcumin to contrast the onset or progression of neurodegeneration and related diseases. Finally, the curcumin safety profile imposes a careful analysis of the risk/benefit balance prior to proposing chronic supplementation with curcumin. |
| topic |
hormesis vitagenes antioxidants heme oxygenase |
| url |
https://www.mdpi.com/2072-6643/11/10/2417 |
| work_keys_str_mv |
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1724723381329199104 |