Chemotherapy-Induced Apoptosis in a Transgenic Model of Neuroblastoma Proceeds Through p53 Induction

Chemotherapy-Induced Apoptosis in a Transgenic Model of Neuroblastoma Proceeds Through p53 Induction

Chemoresistance in neuroblastoma is a significant issue complicating treatment of this common pediatric solid tumor. MYCN-amplified neuroblastomas are infrequently mutated at p53 and are chemosensitive at diagnosis but acquire p53 mutations and chemoresistance with relapse. Paradoxically, Myc-drive...

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Bibliographic Details
Main Authors: Louis Chesler, David D. Goldenberg, Rodney Collins, Matt Grimmer, Grace E. Kim, Tarik Tihan, Kim Nguyen, Slava Yakovenko, Katherine K. Matthay, William A. Weiss
Format: Article
Language:English
Published: Elsevier 2008-11-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558608800243

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http://www.sciencedirect.com/science/article/pii/S1476558608800243

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