Contributions of Cell Metabolism and H+ Diffusion to the Acidic pH of Tumors

The tumor microenvironment is hypoxic and acidic. These conditions have a significant impact on tumor progression and response to therapies. There is strong evidence that tumor hypoxia results from inefficient perfusion due to a chaotic vasculature. Consequently, some tumor regions are well oxygena...

Full description

Bibliographic Details
Main Authors: Paul A. Schornack, Robert J. Gillies
Format: Article
Language:English
Published: Elsevier 2003-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558603800052