Contributions of Cell Metabolism and H+ Diffusion to the Acidic pH of Tumors
The tumor microenvironment is hypoxic and acidic. These conditions have a significant impact on tumor progression and response to therapies. There is strong evidence that tumor hypoxia results from inefficient perfusion due to a chaotic vasculature. Consequently, some tumor regions are well oxygena...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2003-03-01
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Series: | Neoplasia: An International Journal for Oncology Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558603800052 |