Reversible Axonal Dystrophy by Calcium Modulation in Frataxin-Deficient Sensory Neurons of YG8R Mice

Reversible Axonal Dystrophy by Calcium Modulation in Frataxin-Deficient Sensory Neurons of YG8R Mice

Friedreich’s ataxia (FRDA) is a peripheral neuropathy involving a loss of proprioceptive sensory neurons. Studies of biopsies from patients suggest that axonal dysfunction precedes the death of proprioceptive neurons in a dying-back process. We observed that the deficiency of frataxin in sensory neu...

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Bibliographic Details
Main Authors: Belén Mollá, Diana C. Muñoz-Lasso, Fátima Riveiro, Arantxa Bolinches-Amorós, Federico V. Pallardó, Angel Fernandez-Vilata, María de la Iglesia-Vaya, Francesc Palau, Pilar Gonzalez-Cabo
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
rare disease
Friedreich’s ataxia
mitochondria
calcium
neurodegeneration
axonal spheroids
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00264/full

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http://journal.frontiersin.org/article/10.3389/fnmol.2017.00264/full

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