Treatment with K6PC-5, a selective stimulator of SPHK1, ameliorates intestinal homeostasis in an animal model of Huntington's disease

Treatment with K6PC-5, a selective stimulator of SPHK1, ameliorates intestinal homeostasis in an animal model of Huntington's disease

Emerging evidence indicates that Huntington's disease (HD) may be described as multi-organ pathology. In this context, we and others have contributed to demonstrate that the disease is characterized by an impairment of the homeostasis of gastro-intestinal (GI) tract.Sphingolipids represent a cl...

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Bibliographic Details
Main Authors: A. Di Pardo, G. Pepe, L. Capocci, F. Marracino, E. Amico, L. Del Vecchio, S. Giova, S.K. Jeong, B.M. Park, B.D. Park, V. Maglione
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Neurobiology of Disease
Subjects:
K6PC-5
HD
Neurodegeneration
Sphingolipids
Intestinal homeostasis
R6/2 mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120302849

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http://www.sciencedirect.com/science/article/pii/S0969996120302849

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