Tumor–Stroma Cross-Talk in Human Pancreatic Ductal Adenocarcinoma: A Focus on the Effect of the Extracellular Matrix on Tumor Cell Phenotype and Invasive Potential

Tumor–Stroma Cross-Talk in Human Pancreatic Ductal Adenocarcinoma: A Focus on the Effect of the Extracellular Matrix on Tumor Cell Phenotype and Invasive Potential

The extracellular matrix (ECM) in the tumor microenvironment modulates the cancer cell phenotype, especially in pancreatic ductal adenocarcinoma (PDAC), a tumor characterized by an intense desmoplastic reaction. Because the epithelial-to-mesenchymal transition (EMT), a process that provides cancer c...

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Bibliographic Details
Main Authors: Patrizia Procacci, Claudia Moscheni, Patrizia Sartori, Michele Sommariva, Nicoletta Gagliano
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Cells
Subjects:
epithelial-to-mesenchymal transition
E-cadherin
MMPs
cell migration
extracellular matrix remodeling
Online Access:http://www.mdpi.com/2073-4409/7/10/158

Internet

http://www.mdpi.com/2073-4409/7/10/158

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