Improved Antiglioblastoma Activity and BBB Permeability by Conjugation of Paclitaxel to a Cell‐Penetrative MMP‐2‐Cleavable Peptide

Improved Antiglioblastoma Activity and BBB Permeability by Conjugation of Paclitaxel to a Cell‐Penetrative MMP‐2‐Cleavable Peptide

Abstract In order to solve the problems of receptor promiscuity and poor blood‐brain barrier (BBB) penetration in the treatment of glioblastomas (GBM), a novel dual‐functional nanocomplex drug delivery system is developed based on the strategy of peptide‐drug conjugates. In this study, SynB3‐PVGLIG‐...

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Bibliographic Details
Main Authors: Dan Hua, Lida Tang, Weiting Wang, Shengan Tang, Lin Yu, Xuexia Zhou, Qian Wang, Cuiyun Sun, Cuijuan Shi, Wenjun Luo, Zhendong Jiang, Huining Li, Shizhu Yu
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Advanced Science
Subjects:
antiglioblastomas
BBB permeability
MMP‐2
paclitaxel
peptide‐drug conjugations
Online Access:https://doi.org/10.1002/advs.202001960

Internet

https://doi.org/10.1002/advs.202001960

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