Piperlongumine Acts as an Immunosuppressant by Exerting Prooxidative Effects in Human T Cells Resulting in Diminished TH17 but Enhanced Treg Differentiation

Piperlongumine Acts as an Immunosuppressant by Exerting Prooxidative Effects in Human T Cells Resulting in Diminished TH17 but Enhanced Treg Differentiation

Piperlongumine (PL), a natural small molecule derived from the Piper longum Linn plant, has received growing interest as a prooxidative drug with promising anticancer properties. Yet, the influence of PL on primary human T cells remained elusive. Knowledge of this is of crucial importance, however,...

Full description

Bibliographic Details
Main Authors: Jie Liang, Jacqueline D. Ziegler, Beate Jahraus, Christian Orlik, Renata Blatnik, Norbert Blank, Beate Niesler, Guido Wabnitz, Thomas Ruppert, Katrin Hübner, Emre Balta, Yvonne Samstag
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
piperlongumine
primary human T cells
reactive oxygen species
glutathione
TH17 cells
Treg cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01172/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01172/full

Similar Items