Development, validation and comparison of two stability-indicating RP-LC methods using charged aerosol and UV detectors for analysis of lisdexamfetamine dimesylate in capsules

Development, validation and comparison of two stability-indicating RP-LC methods using charged aerosol and UV detectors for analysis of lisdexamfetamine dimesylate in capsules

Two new stability-indicating liquid chromatographic methods using two detectors, an ultraviolet (UV) and a charged aerosol detector (CAD) simultaneously connected in series were validated for the assessment of lisdexamfetamine dimesylate (LDX) in capsule. The method was optimized and the influence o...

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Bibliographic Details
Main Authors: Graciela Carlos, Eloisa Comiran, Marcella Herbstrith de Oliveira, Renata Pereira Limberger, Ana Maria Bergold, Pedro Eduardo Fröehlich
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Arabian Journal of Chemistry
Subjects:
Lisdexamfetamine dimesylate
Stability-indicating
Liquid chromatography
Charged aerosol detector
Stress testing
Plackett–Burman
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535215001720

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http://www.sciencedirect.com/science/article/pii/S1878535215001720

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