Association between CASP8 -652 6N del polymorphism (rs3834129) and colorectal cancer risk: results from a multi-centric study.

The common -652 6N del variant in the CASP8 promoter (rs3834129) has been described as a putative low-penetrance risk factor for different cancer types. In particular, some studies suggested that the deleted allele (del) was inversely associated with CRC risk while other analyses failed to confirm t...

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Main Authors: Barbara Pardini, Paolo Verderio, Sara Pizzamiglio, Carmela Nici, Maria Valeria Maiorana, Alessio Naccarati, Ludmila Vodickova, Veronika Vymetalkova, Silvia Veneroni, Maria Grazia Daidone, Fernando Ravagnani, Tiziana Bianchi, Luis Bujanda, Angel Carracedo, Antoni Castells, Clara Ruiz-Ponte, Hans Morreau, Kimberley Howarth, Angela Jones, Sergi Castellví-Bel, Li Li, Ian Tomlinson, Tom Van Wezel, Pavel Vodicka, Paolo Radice, Paolo Peterlongo, EPICOLON Consortium
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3897464?pdf=render