Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis

Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis

Transcription is tightly regulated to maintain energy homeostasis during periods of feeding or fasting, but the molecular factors that control these alternating gene programs are incompletely understood. Here, we find that the B cell lymphoma 6 (BCL6) repressor is enriched in the fed state and conve...

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Bibliographic Details
Main Authors: Meredith A Sommars, Krithika Ramachandran, Madhavi D Senagolage, Christopher R Futtner, Derrik M Germain, Amanda L Allred, Yasuhiro Omura, Ilya R Bederman, Grant D Barish
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
fasting
steatosis
liver
BCL6
PPAR
repressor
Online Access:https://elifesciences.org/articles/43922

Internet

https://elifesciences.org/articles/43922

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