Inhibitory Effects of <i>Schisandra </i>Lignans on Cytochrome P450s and Uridine 5′-Diphospho-Glucuronosyl Transferases in Human Liver Microsomes

Inhibitory Effects of <i>Schisandra </i>Lignans on Cytochrome P450s and Uridine 5′-Diphospho-Glucuronosyl Transferases in Human Liver Microsomes

<i>Schisandra chinensis</i> has been widely used as a traditional herbal medicine to treat chronic coughs, fatigue, night sweats, and insomnia. Numerous bioactive components including lignans have been identified in this plant. Lignans with a dibenzocyclooctadiene moiety have been known...

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Bibliographic Details
Main Authors: Hyung-Ju Seo, Seung-Bae Ji, Sin-Eun Kim, Gyung-Min Lee, So-Young Park, Zhexue Wu, Dae Sik Jang, Kwang-Hyeon Liu
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceutics
Subjects:
<i>Schisandra chinensis</i>
lignans
cytochrome P450
uridine 5′-diphosphoglucuronosyl transferase
drug interaction
Online Access:https://www.mdpi.com/1999-4923/13/3/371

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https://www.mdpi.com/1999-4923/13/3/371

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