FMS-LIKE TYROSINE KINASE (FLT3) GENE ITD MUTATION IN ACUTE MYELOID LEUKEMIA

FMS-LIKE TYROSINE KINASE (FLT3) GENE ITD MUTATION IN ACUTE MYELOID LEUKEMIA

<p>Background. FLT3 is a class III receptor tyrosine kinase expressed in normal stem cells and blasts of myeloid leukemia. Internal tandem duplication (ITD) of the FLT3 gene affecting the exons 14 and 15 leads to ligand-independent FLT3 dimerization and constitutive activation. This stimulates...

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Bibliographic Details
Main Authors: Rajko Kusec, Maruska Marusic Vrsalovic, Tanja Vranic Bobetic, Slobodanka Ostojic, Hrvoje Mingo, Branimir Jaksic
Format: Article
Language:English
Published: Slovenian Medical Association 2004-12-01
Series:Zdravniški Vestnik
Subjects:
FLT3 gene
leukemia
internal tandem duplication
prognostics
cytogenetics
Online Access:http://vestnik.szd.si/index.php/ZdravVest/article/view/2413

Internet

http://vestnik.szd.si/index.php/ZdravVest/article/view/2413

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