Histone Deacetylase Expressions in Hepatocellular Carcinoma and Functional Effects of Histone Deacetylase Inhibitors on Liver Cancer Cells In Vitro

Histone Deacetylase Expressions in Hepatocellular Carcinoma and Functional Effects of Histone Deacetylase Inhibitors on Liver Cancer Cells In Vitro

Hepatocellular carcinoma (HCC) is a leading cause for deaths worldwide. Histone deacetylase (HDAC) inhibition (HDACi) is emerging as a promising therapeutic strategy. However, most pharmacological HDACi unselectively block different HDAC classes and their molecular mechanisms of action are only inco...

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Bibliographic Details
Main Authors: Kim Freese, Tatjana Seitz, Peter Dietrich, Serene M.L. Lee, Wolfgang E. Thasler, Anja Bosserhoff, Claus Hellerbrand
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
histone deacetylase
hepatocellular carcinoma
sorafenib
histone deacetylase inhibitor
Online Access:https://www.mdpi.com/2072-6694/11/10/1587

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https://www.mdpi.com/2072-6694/11/10/1587

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