The human, F-actin-based cytoskeleton as a mutagen sensor

The human, F-actin-based cytoskeleton as a mutagen sensor

Abstract Background Forty years ago the actin cytoskeleton was determined to be disrupted in fibroblasts from persons with DNA repair-defective, hereditary colon cancer, with no clear connection between the cytoskeleton and DNA repair defects at that time. Recently, the large number of sequenced gen...

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Bibliographic Details
Main Authors: Nicolette M. Clark, Carlos A. Garcia Galindo, Vandan K. Patel, Michele L. Parry, Rebecca J. Stoll, John M. Yavorski, Elizabeth P. Pinkason, Edna M. Johnson, Chelsea M. Walker, Joseph Johnson, Wade J. Sexton, Domenico Coppola, George Blanck
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Cancer Cell International
Subjects:
Mutation frequency
Cytoskeleton
Chemotherapy sequelae
Smoking mutations
Online Access:http://link.springer.com/article/10.1186/s12935-017-0488-5

Internet

http://link.springer.com/article/10.1186/s12935-017-0488-5

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