miR-541-3p enhances the radiosensitivity of prostate cancer cells by inhibiting HSP27 expression and downregulating β-catenin

Abstract Heat shock protein 27 (HSP27), a regulator of cell survival, can enhance the resistance of cancer cells to radiotherapy. As microRNA-541-3p (miR-541-3p) was recently predicted to be a putative upstream modulator of HSP27, the present study was designed to investigate the function and mechan...

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Bibliographic Details
Main Authors: Zhenhua He, Fuhui Shen, Ping Qi, Zhenxing Zhai, Zhiping Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-020-00387-8