An Improved Method for the Synthesis of Butein Using SOCl<sub>2</sub>/EtOH as Catalyst and Deciphering Its Inhibition Mechanism on Xanthine Oxidase

An Improved Method for the Synthesis of Butein Using SOCl<sub>2</sub>/EtOH as Catalyst and Deciphering Its Inhibition Mechanism on Xanthine Oxidase

Butein (3,4,2&#8242;,4&#8242;-tetrahydroxychalcone) belongs to the chalcone family of flavonoids and possesses various biological activities. In this study, butein was synthesized through aldol condensation catalyzed by thionyl chloride (SOCl<sub>2</sub>)/ethyl alcohol (EtOH) for...

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Bibliographic Details
Main Authors: Yu-Xue Hou, Shi-Wei Sun, Yang Liu, Yan Li, Xiao-Hong Liu, Wei Wang, Shuang Zhang
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
butein
SOCl<sub>2</sub>/EtOH
xanthine oxidase
inhibitory mechanism
kinetic analysis
florescence spectroscopy
molecular docking
Online Access:https://www.mdpi.com/1420-3049/24/10/1948

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https://www.mdpi.com/1420-3049/24/10/1948

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