Characterization of a Novel Compound That Stimulates STING-Mediated Innate Immune Activity in an Allele-Specific Manner

Characterization of a Novel Compound That Stimulates STING-Mediated Innate Immune Activity in an Allele-Specific Manner

The innate immune response to cytosolic DNA involves transcriptional activation of type I interferons (IFN-I) and proinflammatory cytokines. This represents the culmination of intracellular signaling pathways that are initiated by pattern recognition receptors that engage DNA and require the adaptor...

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Bibliographic Details
Main Authors: Jinu Abraham, Sara Botto, Nobuyo Mizuno, Kara Pryke, Bryan Gall, Dylan Boehm, Tina M. Sali, Haihong Jin, Aaron Nilsen, Michael Gough, Jason Baird, Marita Chakhtoura, Caroline Subra, Lydie Trautmann, Elias K. Haddad, Victor R. DeFilippis
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
interferon
cytokine
cytosolic DNA sensing
STING
adjuvant
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01430/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01430/full

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