IL7Rα expression and upregulation by IFNβ in dendritic cell subsets is haplotype-dependent.

The IL7Rα gene is unequivocally associated with susceptibility to multiple sclerosis (MS). Haplotype 2 (Hap 2) confers protection from MS, and T cells and dendritic cells (DCs) of Hap 2 exhibit reduced splicing of exon 6, resulting in production of relatively less soluble receptor, and potentially m...

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Bibliographic Details
Main Authors: Fiona C McKay, Edwin Hoe, Grant Parnell, Prudence Gatt, Stephen D Schibeci, Graeme J Stewart, David R Booth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3797747?pdf=render