Phenoxybenzamine Is Neuroprotective in a Rat Model of Severe Traumatic Brain Injury

Phenoxybenzamine (PBZ) is an FDA approved α-1 adrenergic receptor antagonist that is currently used to treat symptoms of pheochromocytoma. However, it has not been studied as a neuroprotective agent for traumatic brain injury (TBI). While screening neuroprotective candidates, we found that phenoxybe...

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Bibliographic Details
Main Authors: Thomas F. Rau, Aakriti Kothiwal, Annela Rova, Joseph F. Rhoderick, David J. Poulsen
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:http://www.mdpi.com/1422-0067/15/1/1402