Endoplasmic reticulum stress as target for treatment of hearing loss

Endoplasmic reticulum stress as target for treatment of hearing loss

The endoplasmic reticulum (ER) plays pivotal roles in coordinating protein biosynthesis and processing. Under ER stress, when excessive misfolded or unfolded proteins are accumulated in the ER, the unfolded protein response (UPR) is activated. The UPR blocks global protein synthesis while activates...

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Bibliographic Details
Main Authors: Yanfei Wang, Zhigang Xu
Format: Article
Language:English
Published: Innovation Publishing House Pte. Ltd. 2020-03-01
Series:STEMedicine
Subjects:
ER stress
Unfolded protein response (UPR)
Hearing loss
Inner ear
Cochlea
Online Access:https://stemedicine.org/index.php/stem/article/view/21

Internet

https://stemedicine.org/index.php/stem/article/view/21

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